National University Health System, Singapore
The Liver & COVID-19
Prof. Lim Seng Gee
Key concerns during COVID-19 for impact on the liver
Does COVID-19 affect the liver, and how bad is it?
How does COVID-19 affect those with liver disease?
Frequency of Abnormal LFTS during COVID
3381 patients tested in 3 US Hospitals of which 2273 patients tested positive
COVID can cause abnormal LFTS during the course of illness However these are usually mild
Phipps, Hepatology 2020 May 30 (in press)
Factors associated with ALT>5x ULN
Severe COVID is associated with high levels of abnormal ALT
n=145 out of 2273 patients
Phipps, Hepatology 2020 May 30 (in press)
Deaths in patients with Chronic Liver Disease who have COVID-19
152 consecutive patients with CLD and COVID-19 from a Disease Registry
Death in those with liver disease and COVID is related to cirrhosis status
Moon, J Hepatol May 2020 (in press)
Risk factors associated with mortality in CLD
Those with the worse liver function (CTP C cirrhosis) have the highest risk of death
Moon, J Hepatol May 2020 (in press)